Migraine Resource Network is a comprehensive educational initiative for clinicians seeking current and emerging information on migraine headache. Our mission is to provide ongoing medical education that embodies evidence-based scientific data, current treatment strategies, and the insightful knowledge of expert faculty. Our goal is to support your ongoing dedication to optimizing treatment outcomes for your patients.

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Mysteries and Mechanisms of Migraine

Release Date: December 19, 2008
Expiration Date: December 19, 2009

Program Overview

Migraine disorder is widespread and affects children and men, but is most prevalent in women during their reproductive life cycle. Migraine negatively affects health-related quality of life, impacts social and employment activities, is frequently accompanied by various comorbid conditions, and is considered a public health issue due to significant levels of disability and related costs.

Pioneers in medical research have laid the foundation for today’s research initiatives. Advances in medical imaging, such as Blood Oxygen Level Dependent (BOLD) Functional Magnetic Resonance Imaging (fMRI), Diffusion and Perfusion Weighted Imaging (DWI; PWI), Magnetoencephalograms (MEG), and Positron Emission Tomography (PET) have all provided valuable data to help demonstrate pathophysiologic mechanisms that assist in the correlation of migraine aura and pain. Genetic mutations, estrogen fluctuations, interictal disturbances leading to chronification, and other mechanisms appear to directly contribute to migraine onset, frequency and severity.

Dr. Aurora discusses early research discoveries in migraine and quickly advances to the latest research findings in an effort to assist practitioners in their understanding of the complex mechanisms involved with this formidable and debilitating condition.

Target Audience

This activity is designed for physicians involved in management of migraine.

Learning Objectives

After completion of this educational activity, participants will be able to:

  1. Distinguish the increase in prevalence of migraine in women compared to men
  2. Sequence the neuro-dynamics associated with aura
  3. State the role of hormone fluctuations in migraine onset
  4. Articulate why women with menstrual-related migraine rarely report aura

General Information

This activity is eligible for credit through December 19, 2009. After this date, this activity will expire and no further credit will be awarded.

Expected time to complete this activity as designed: 30 minutes

There are no fees for participating in this activity. All participants must complete the Activity Evaluation Form. Participants must receive a minimum score of 70% on the self-assessment portion of the form to qualify for CE credit. Certificates may be printed immediately after successfully completing the online self-assessment and evaluation.

Faculty Biography

Sheena Aurora, MD
Swedish Headache Center
Seattle, Washington

Dr. Sheena Aurora is past medical director of the Headache Clinic at Henry Ford Hospital in Detroit. She is board certified in neurology and electrodiagnostic medicine. She has extensive experience in hyperkinetic-movement disorders including dystonia and dysphonia. In addition to routine electromyograms (EMGs), she also conducts special studies including transcranial magnetic stimulation, autonomic studies, and laryngeal and pudendal EMGs. Dr. Aurora has been widely published and lectures frequently. An experienced researcher, Dr. Aurora was one of the principal investigators of the first migraine program project funded by the National Institutes of Health. Her areas of research include headache, migraine, movement disorders, and various topics in neurophysiology.


MediCom LogoAccreditation Statement: This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of MediCom Worldwide, Inc. and Medical Learning Solutions. MediCom Worldwide, Inc. is accredited by the ACCME to provide continuing medical education for physicians.
Designation Statement: MediCom Worldwide, Inc. designates this educational activity for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.


In accordance with the Accreditation Council for Continuing Medical Education (ACCME), ACPE and California Board of Nursing, MediCom Worldwide, Inc. requires that all program planners, faculty, and providers who are in a position to control the content of a CE activity are required to disclose any relevant financial relationships they may have or have had within the last 12 months with the commercial supporter or the manufacturer(s) of any commercial device(s) discussed in this educational activity. Accordingly the following disclosures were made.

Faculty Disclosure

The presenting faculty reported the following: Dr. Sheena Aurora has received honoraria from AstraZeneca PLC; Merck & Co. Inc.; GlaxoSmithKline; Ortho-McNeil (Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc.); and Valeant Pharmaceuticals International, as well as consultant fees from Ortho-McNeil; AstraZeneca; Merck; GlaxoSmithKline; Pfizer Inc.; Allergan Inc.; and NMT Medical. She has received grant support related to research activities from Alexza Pharmaceuticals; GlaxoSmithKline; AstraZeneca; Allergan; Winston Laboratories; and Merck.

Planner and Provider Disclosure

The individuals listed below from MediCom Worldwide, Inc. reported the following for this activity: Joan Meyer, executive director; Norma Jean Talley, manager, professional education; and Ruth Widmer, medical editor, have nothing to disclose.

Off-Label/Investigational Disclosure

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The opinions expressed in the educational activity are those of the faculty. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings. Further, attendees/participants should appraise the information presented critically and are encouraged to consult appropriate resources for any product or device mentioned in this program.

Dr. Aurora indicated that her presentation would not include the discussion of unlabeled uses of commercial products or investigational products not yet approved by the FDA for any use in the United States.

Conflict of Interest Resolution

To resolve identified conflicts of interest, the educational content was fully peer reviewed by members of the MediCom Content Review Committee. The resulting certified activity was found to provide educational content that is current, evidence-based, and commercially balanced.

This activity is supported by an independent educational grant from
Endo Pharmaceuticals.

©2008 MediCom Worldwide, Inc., 101 Washington St., Morrisville, PA 19067. No portion of this material may be copied or duplicated without written permission of MediCom.

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